This 3D Printer Can Create Complex Biological Tissues
⯀ Researchers have created a new 3D biopriting technique that is capable of producing complex tissues. The proposed system provides a robust platform for bioprinting applications in tissue engineering, regenerative medicine, and biosensing, which are otherwise not readily achievable at high speed with conventional stereolithographic biofabrication platforms.
Researchers have developed a technique that uses a specially adapted 3D printer to build therapeutic biomaterials from multiple materials. The advance could be a step toward on-demand printing of complex artificial tissues for use in transplants and other surgeries.
"Our new approach offers a way to build complex biocompatible structures made from different materials."
“Tissues are wonderfully complex structures, so to engineer artificial versions of them that function properly, we have to recreate their complexity,” said Ali Khademhosseini, who led the study and is UCLA’s Levi James Knight, Jr., Professor of Engineering at the UCLA Samueli School of Engineering. “Our new approach offers a way to build complex biocompatible structures made from different materials.”
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The study was was published in the journal Advanced Materials. Using a light-based process called stereolithography, the technique takes advantage of a customized 3D printer designed by Khademhosseini that has two key components. The first is a custom-built microfluidic chip — a small, flat platform similar in size to a computer chip — with multiple inlets that each “prints” a different material. The other component is a digital micromirror, an array of more than a million tiny mirrors that each moves independently.
The team used different types of hydrogels – materials that, after passing
through the printer, form scaffolds for tissue to grow into. The
micromirrors direct light onto the printing surface, and the illuminated
areas indicate the outline of the 3D object that’s being printed.
Light also triggers molecular bonds to form in the materials, which
causes the gels to firm into solid material. As the 3D object is
printed, the mirror array changes the light pattern to indicate the
shape of each new layer.
The process is the first to use multiple materials for automated stereolithographic bioprinting — an advance over conventional stereolithographic bioprinting, which only uses one type of material. While the demonstration device used four types of bio-inks, the study’s authors write that the process could accommodate as many inks as needed.
The researchers first used the process to make simple shapes, such as pyramids. Then, they made complex 3D structures that mimicked parts of muscle tissue and muscle-skeleton connective tissues. They also printed shapes mimicking tumors with networks of blood vessels, which could be used as biological models to study cancers. They tested the printed structures by implanting them in rats. The structures were not rejected.
The process is the first to use multiple materials for automated stereolithographic bioprinting — an advance over conventional stereolithographic bioprinting, which only uses one type of material. While the demonstration device used four types of bio-inks, the study’s authors write that the process could accommodate as many inks as needed.
The researchers first used the process to make simple shapes, such as pyramids. Then, they made complex 3D structures that mimicked parts of muscle tissue and muscle-skeleton connective tissues. They also printed shapes mimicking tumors with networks of blood vessels, which could be used as biological models to study cancers. They tested the printed structures by implanting them in rats. The structures were not rejected.
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